Zinc Supplementation in Children with Asthma Exacerbation
نویسندگان
چکیده
Zinc deficiency has demonstrated an association with the risk of asthma. This study aimed to evaluate the efficacy of zinc supplementation in reducing the severity of childhood asthma exacerbation. A number of 42 children with asthma exacerbation admitted to the hospital were randomized to receive either zinc bis-glycinate (30 mg elemental zinc/day) or a placebo in adjuvant to the standard treatment. The pediatric respiratory assessment measure (PRAM) was used to measure the asthma severity. The primary outcome was a change in asthma severity from the baseline to the end of study. The study found that PRAM score in the zinc group showed a more rapid decrease compared to the control group at the 24-hour (2.2±1.3 vs. 1.2±1.3; P = 0.015) and 48-hour (3.4±2.0 vs. 2.2±1.8; P = 0.042) intervals. At admission, overall mean serum zinc level was 63.8 mg/dL and 57.1% of children had zinc deficiency with no difference in prevalence between groups. PRAM scores did not differ between children with low and normal zinc status. In conclusion, zinc supplementation as the adjuvant therapy to the standard treatment during asthma exacerbation resulted in rapid lessening of severity.
منابع مشابه
Spirometry Findings Following Treatment with Oral and Inhalant Corticosteroids in Mild to Moderate Asthma Exacerbation in Children
Introduction: Asthma exacerbation is common in children. Treatment with oral corticosteroids (OCS) and inhaled corticosteroids are suggested for asthma exacerbation. It is shown that inhaled corticosteroids has similar outcome in reducing asthma symptoms compared to OCS. But few studies have evaluated the pulmonary function changes in these two treatments. In this study, we evaluated the chang...
متن کاملSerum, hair and nail Zinc level in children with asthma; zinc supplemental treatment in children with asthma: a systematic and meta-analysis review article
متن کامل
Effect of zinc supplementation in children with asthma: a randomized, placebo-controlled trial in northern Islamic Republic of Iran.
There are conflicting reports about the benefits of zinc supplements in childhood asthma. This study examined the effect of zinc supplementation in children with asthma attending an outpatient clinic in Sari, Islamic Republic of Iran. In a randomized, double-blind, placebo-controlled clinical trial over 8 weeks, 284 children on inhaled steroids were allocated to receive zinc supplements (50 mg/...
متن کاملEffect of oral supplementation of zinc on treatment of otitis media with effusion
Abstract Objective: To determine the effect of oral zinc sulfate supplementation given with coamoxiclav when compared with coamoxiclav alone for treatment of otitis media with effusion (OME). The efficacy of the drug was assessed 3 and 6 weeks after administration . Methods: In a double-blind, randomized trial 4 to 14 years old children with OME who referred to ear, nose and throat ...
متن کاملبررسی غلظت روی سرم و تأثیر مکمل یاری با روی بر عملکرد تنفسی بیماران بتلا به آسم
Background and Aim: Asthma, as the most prevalent disorder of the airways is accompanied with excessive inflammatory, oxidative and apoptotic activity. In asthmatic patients, serum and hair levels of zinc are decreased. Zinc, as an essential micronutrient for human is reported to have anti inflammatory, anti oxidant and anti apoptosis roles. This study was conducted to investigate the effec...
متن کامل